Lupus anticoagulant-hypoprothrombinemia in healthy adult

A mechanism for the hypoprothrombinemia of the acquired hypoprothrombinemia-lupus anticoagulant syndrome.

Antibodies that bind prothrombin without neutralizing its coagulant activity were demonstrated in the plasma of two patients with the acquired hypoprothrombinemia-lupus anticoagulant syndrome. The first patient's plasma contained less than 1% prothrombin activity and no detectable prothrombin antigen. The second patient's plasma contained about 6% of both prothrombin activity and antigen. Neith...

Pulmonary hemorrhage in pediatric lupus anticoagulant hypoprothrombinemia syndrome

Lupus anticoagulant-hypoprothrombinemia syndrome (LAHPS), a very rare disease that is caused by the presence of antifactor II antibodies, is usually counterbalanced by the prothrombotic effect of lupus anticoagulant (LAC). Patients with LAHPS are treated using fresh frozen plasma, steroids, immunosuppressive agents, and immunoglobulins for managing the disease and controlling hemorrhages. Notab...

Successful treatment of acquired hypoprothrombinemia without associated lupus anticoagulant using intravenous immunoglobulin.

A plasma coagulation defect in systemic lupus erythematosus arising from hypoprothrombinemia combined with antiprothrombinase activity.

By SAMUEL I. RAPAPORT, S r A BETH AMES AND BARBARA J. DUVALL C ONLEY AND HARTMANN’ first called attention to a plasma coagulation disturbance peculiar to patients with systemic lupus erythematosus or closely related dysproteinemias. Its characteristics are a long whole blood and/or recalcified plasma clotting time, a long Quick “prothrombin” time, and the presence of a circulating anticoagulant...

Anti-prothrombin antibodies and the lupus anticoagulant.

The investigators have evaluated the frequency and manifestations of anti-prothrombin antibodies in patients with the lupus anticoagulant. Thirty-one of 42 patients with lupus anticoagulants associated with a variety of underlying conditions (74%) had evidence on crossed immunoelectrophoresis of anti-prothrombin antibodies. Twenty-four of 25 patients with an activated partial thromboplastin tim...